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Deepak Kaushik

Research interests
Multiple sclerosis (MS) is a highly inflammatory, demyelinating, and degenerative condition of the central nervous system (CNS). Due to its high prevalence within the country, MS is often referred to as “Canada’s disease”. Immune cells including T-cells, B- cells, macrophages and microglia (brain resident macrophages), among others, play important roles in the manifestation and progression of MS. ‘Immunometabolism’ is a newer discipline of Immunology which focuses on understanding the metabolic needs (energy requirements) of immune cells as they execute their functions. Our Lab focuses on understanding the role of different metabolic pathways that guide monocytes/macrophages and microglia to dictate neuroinflammation during MS pathogenesis. Using primary cell cultures, transgenic mouse models, and high throughput techniques such as scRNA-seq, we are exploring roles for novel immunometabolic players in the manifestation of MS pathogenesis. In addition to studying MS, we are also interested in identifying metabolic pathways that help microglia efficiently prune weaker synapses during the brain development. 

We are currently seeking applications from highly motivated students with an immunology background for either master’s or Ph.D. program. If interested, please forward one page Research Statement along with a CV and applicable transcripts to dkaushik@mun.ca.

A confocal image of a cerebellar section of an EAE brain (a mouse model of MS) abutting the 4th ventricle. Meningeal inflammation is prominent during peak disease severity in EAE brains. Laminin (green) labels the basement membranes and CD45 (red) stains the immune cells as they transmigrate the CNS through the meninges. Kaushik Lab

PUBLICATIONS (2016-2022)

Ghorbani S, Jelinek E, Jain R, Buehner B, Li C, Lozinski BM, Sarkar S, Kaushik DK, Dong Y, Wight TN, Karimi-Abdolrezaee S, Schenk GJ, Strijbis EM, Geurts J, Zhang P, Ling CC, Yong VW. Nat Commun. 2022 May 4;13(1):2445.

Kaushik DK, Bhattacharya A, Lozinski BM, Wee Yong V. J Neuroinflammation. 2021 Dec 24;18(1):301.

Rawji KS, Kaushik DK. Front Editorial: Frontiers in Aging Neurosci. 2021 Aug 20;13:742620

Dong Y, Charlotte D’Mello, Moezzi D, Lozinski B, Kaushik DK, Ghorbanigazar S, Brown D, Francisca C. Melo, Tina Vo, and Yong VW. . Nat Neuroscience. 2021 Apr;24(4):489-503

Kataria H, Hart CG, Alizadeh A, Cossoy M, Kaushik DK, Bernstein CN, Marrie RA, Yong VW, Karimi-Abdolrezaee S. Brain. 2021 Feb 12;144(1):162-185.

Morgan ML, Kaushik DK, Stys PK, Caprariello AV. Mult Scler. 2021 Jun;27(7):1046-1056.

Kaushik DK, Yong VW J Neurochem. 2020 Oct 6. doi: 10.1111/jnc.15206.

Bhattacharya A, Kaushik DK*, Lozinski BM, Yong VW. J Neurosci Res. 2020 Dec;98(12):2390-2405. *co-first authors

Rawji KS, Young A, Ghosh T, Michaels NJ, Mirzaei R, Mishra MK, Kappen J, Kohlemainen K, Pu A, Tang W, Zein S, Kaushik DK, Keough MB, Plemel J, Calvert F, Knights A, Gaffney D, Tetzlaff W, Franklin RJM, Yong VW. Acta Neuropathologica, 2020 Feb 6. doi: 10.1007/s00401-020-02129-7

Kaushik DK, Bhattacharya A, Mirzaei R, Rawji KS, Ahn Y, Rho JM, Yong VW. J Clin Invest. 2019 May 21;130. doi: 10.1172/JCI124012.

Faissner S, Mishra M, Kaushik DK, Wang J, Fan Y, Silva C, Rauw G, Metz L, Koch M, Yong VW. Nat Comm. 2017 Dec; 8(1):1990

Hahn JN, Kaushik DK, Mishra MK, Wang J, Silva C, Yong VW. J Immunol. 2016 Nov 15;197(10):3850-3860

Kaushik DK, Yong HY, Hahn JN, Silva C, Casha S, Hurlbert RJ, Jacques FH, Lisak R, Khan O, Ionete C, Larochelle C, Prat A, Bar-Or A, Yong VW. . PLoS One. 2016 Oct 11;11(10):e0163802.

 
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